By Robert Preidt
FRIDAY, Oct. 9, 2020 (HealthDay Information) — The so-called love hormone, oxytocin, could also be price investigating as a remedy for COVID-19, a brand new examine suggests.
One of the vital severe problems of an infection with the new coronavirus is a “cytokine storm,” wherein the physique assaults its personal tissues.
There are presently no U.S. Meals and Drug Administration-approved remedies for COVID-19, which implies that “repurposing current medication that may act on the adaptive immune response and stop the cytokine storm in early phases of the illness is a precedence,” in keeping with the researchers.
On this new examine, researcher Ali Imami, a graduate analysis assistant on the College of Toledo in Ohio, and colleagues used a U.S. Nationwide Institutes of Well being database to investigate traits of genes handled with medication intently associated to oxytocin.
The investigators discovered that one drug specifically, carbetocin, has comparable traits (referred to as a signature) to genes with decreased expression of the inflammatory markers that set off cytokine storm in COVID-19 sufferers.
Carbetocin’s signature means that the drug might set off activation of immune cells referred to as T-cells that play an vital function in immune response. As well as, carbetocin’s signature can be much like that of lopinavir, an antiretroviral treatment beneath examine as a remedy for COVID-19.
All of those elements point out that oxytocin might have potential as a focused remedy for cytokine storms in COVID-19 sufferers, the researchers stated in a information launch from the American Physiological Society.
“Understanding the mechanisms by which oxytocin or the oxytocin system is usually a new immune goal is essential,” the authors concluded of their report, which was printed on-line just lately within the journal Physiological Genomics.
Nevertheless, they added that “security and efficacy of intravenous oxytocin in hospitalized sufferers with COVID-19 stays to be assessed.”